In this case–control study of Chine

In this case–control study of Chinese NSCLC patients and healthy
control patients, we determined an association between XRCC3 and
XRCC4 SNPs or other known risk factors and NSCLC susceptibility.
We found five SNPs, including rs861537 and rs1799794 in XRCC3
and rs6869366, rs1056503 and rs9293337 in XRCC4, to be associated
with NSCLC risk in both adjusted and unadjusted models. For
example, the rs1799794 G allele in the XRCC3 gene was inversely
associated with NSCLC risk (GG vs homozygote AA), whereas the
rs861537 AG or AA genotype and XRCC4 rs6869366 had a
significantly increased NSCLC risk. In contrast, minor allele carriers
of XRCC4 rs1056503 and rs9293337 were inversely associated with
NSCLC risk. In addition, 26 pack-year tobacco smokers, a family
history of lung cancer, ETS exposure, CGAA/CGAA in XRCC3 and a
negative mental status were risk factors in NSCLC development. The
data from this study indicate that gene–environment interactions have
an important role in NSCLC development.
Previous studies showed that rs1799794 was a prognostic indicator
for radiation and chemotherapy in NSCLC and a miR-328 binding
site.26,27 Moreover, the SNP marker rs861537 was in the subset of
tagging SNPs identified by the Haploview Program and mapped to
the intron region of XRCC3. This polymorphism was first shown to
contribute to NSCLC risk in this study. However, to date, there is a
lack of biological mechanistic and epidemiological data to support
this finding. A recent study demonstrated that the rs861537 SNP was
associated with the risk of lung, colorectal and breast cancer.28
Another study showed that rs861539 was associated with G2
chromosomal radiosensitivity and could have a protective role in
cancer susceptibility.29 However, the same group 4 years later failed to
repeat their previous data on the association between rs861539 and
cancer risk or G(2) chromosomal radiosensitivity.30 Meta-analysis19,31
studies concluded that this SNP might have not been associated with
lung cancer risk. However, our current study demonstrated that
XRCC3 rs861537 was associated with an increased risk of NSCLC,
whereas the minor allele carriers of XRCC3 rs1799794 were inversely
associated with NSCLC risk.

ผลลัพธ์ (อังกฤษ) 3:

This In case - Control study of Chinese NSCLC
patients and healthy control patients, we determined an association between 3 and
XRCC XRCC SNPs 4 or other known risk factors and susceptibility NSCLC.
We SNPs found five, including RS and RS 861537 and 1799794 in XRCC 3
RS 6869366, RS RS 1056503 and 9293337 in XRCC 4, to be associated with
NSCLC risk in both adjusted and unadjusted models. For
example,The RS 1799794 G XRCC 3 allele in the gene was inversely associated with
NSCLC risk (GG AA vs homozygote), whereas the RS 861537
AG or AA XRCC genotype 4 and RS 6869366
had a significantly increased risk NSCLC. In contrast, minor allele carriers of
XRCC RS 4 RS 1056503 and 9293337 were inversely associated with risk
NSCLC. In addition, 26 pack-year tobacco smokers,
a family history of lung cancer,ETS exposure, CGAA/CGAA XRCC in
3 and a negative mental status were risk factors in development NSCLC. The
data from this study indicate that
gene - environment interactions have an important role in development NSCLC.
Previous studies showed that RS 1799794
was a prognostic indicator for radiation and chemotherapy in a NSCLC and miR - 328 binding site
.26, 27 Moreover,The SNP marker was in the subset of RS 861537
tagging SNPs identified by the Haploview Program
and mapped to the region of intron XRCC 3. This polymorphism was first shown to
NSCLC contribute to risk in this study. However, to date, there is a lack of biological mechanistic
and
epidemiological data to support this finding. A recent study demonstrated that the RS 861537 SNP was
associated with the risk of lung, colorectal and breast cancer & Rt.28
Another study showed that RS 861539 was associated with chromosomal radiosensitivity G 2
and
could have a protective role in cancer susceptibility .. 29However, 4 years later the same group
failed to repeat their previous data on the association between RS 861539 and
G or cancer risk (2) chromosomal radiosensitivity Meta 30-analysis 19,31
SNP studies concluded that this might not have been associated with lung cancer risk
. However, our current study demonstrated that
XRCC RS 861537 3 was associated with an increased risk of NSCLC,
whereas the minor allele carriers of RS 1799794 XRCC 3
were inversely associated with NSCLC risk.