Leptospirosis is an important global human and veterinary health problem caused by pathogenic bacteria belonging to the. Genus Leptospira. Chronically infected reservoir host animals shed leptospires into the environment in their urine. Contact. With contaminated soil or water results in large numbers of leptospiral infections in animals and people each year. The. Goal of our research is to develop safe and effective vaccines and accurate rapid-diagnostic tests to prevent the severe. And potentially life-threatening complications of leptospirosis.Leptospiral Membrane Architecture.Our current model of leptospiral membrane architecture is based upon development of reliable leptospiral membrane fraction. Techniques (10 12), and assays for surface-exposure of leptospiral outer membrane, proteins (4 12). We have shown that the. Components of the outer membrane of pathogenic Leptospira species include lipopolysaccharide (LPS), the porin OmpL1 (7,, 20) and several lipoproteins including LipL21 (3), LipL32 (8), LipL36 (9), LipL41, (12 21), LipL46 (15), LigA and LigB,, (13). Of these LipL36 is, restricted to the inner leaflet of the leptospiral outer membrane (21). We have developed controls. For contamination of outer membrane preparations consisting of antisera to subsurface antigens including the periplasmic. Endoflagella (EF), the cytoplasmic membrane proteins LipL31 LipL71 and ImpL63 and,,, the cytoplasmic protein GroEL (10).
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