in the presence of PDGF-BB, the combination of the capture probe and the detection probe leads to the modification of invertase on the surfaces of SA-PMPs. And invertase could catalyze the hydrolysis of sucrose into glucose and fructose (Paine et al., 1925), resulting in a much higher signal detected by the PGM. The change in the PGM values has a relationship with the PDGF-BB concentration, and a sensitive biosensor for PDGF-BB determination based on this principle can be developed.